Methyl 2-acetamido-2-(1-acetyl-3-hydroxy-2-oxoindolin-3-yl)propanoate
نویسندگان
چکیده
In the title isatin compound, C(16)H(18)N(2)O(6), the pyrrolidine ring adopts an envelope conformation and is inclined at a dihedral angle of 7.31 (5)° with respect to the benzene ring. The acetyl group is disordered over two positions with refined occupancies of 0.503 (4) and 0.497 (4). These groups make dihedral angles of 12.6 (6) and 19.6 (7)° with the pyrrolidine ring. In the crystal structure, inter-molecular C-H⋯O hydrogen bonds link neighbouring mol-ecules into infinite chains along the b axis. These chains are further inter-connected by inter-molecular O-H⋯O hydrogen bonds into two-dimensional arrays parallel to the bc plane. Weak inter-molecular C-H⋯π inter-actions further stabilize the crystal structure.
منابع مشابه
Design, Synthesis and antiHIV activity of Novel Isatine-Sulphonamides
A series of novel isatine-sulphonamide derivatives have been synthesized by combining isatin derivatives with sulphonamides. The structure of the synthesized compounds were elucidated by spectral analysis (IR, NMR and Mass). Investigation of anti-HIV activity was done against HIV-1(IIIB) in MT-4 cells and HIV integrase inhibitory activity. 4-(1-acetyl-5-methyl-2-oxoindolin-3-ylideneamino)-N-(4,...
متن کامل( 2 S ) - [ 3 - ( Anthracen - 9 - yl ) - 4 , 5 - dihydroisoxazol - 5 - yl ] methyl 2 - [ ( tert - butoxycarbonyl ) amino ] propanoate
The synthesis of the (2S)-[3-(anthracen-9-yl)-4,5-dihydroisoxazol-5-yl]methyl 2-[(tert-butoxycarbonyl)amino]propanoate is obtained through the 1,3-dipolar cycloaddition of the stable anthracenenitrile oxide and the N-Boc protected (S)-alanine allyl ester as dipolarophile. The structure and the fluorescence properties are described upon the relative analytical and spectroscopic data.
متن کاملIn vitro cytotoxic activity evaluation of phenytoin derivatives against human leukemia cells.
Hydantoin derivatives, including phenytoin (5,5-diphenylhydantoin), have recently gained attention as they possess a variety of important biochemical and pharmacological properties. Nevertheless, available information on anticancer activity of hydantoin derivatives is still scarce. Here, we evaluated possible antileukemic potential of four phenytoin analogs, namely: methyl 2-(2,4-dioxo-5,5-diph...
متن کاملN-(3-Substituted-benzylidene-2-oxoindolin-5-yl)acetamide Derivatives as Src Kinase Inhibitors: Synthesis, Biological Evaluation and Molecular Docking Studies
The synthesis of new N-(3-substituted-benzylidene-2-oxoindolin-5-yl) acetamide (5-14) derivatives along with their inhibitory activity against Src is reported. Among all compounds, only 10, 12 and 13 were found slightly active against Src with IC50 values of 3.55, 6.39 and 7.29 mM, respectively. Docking studies have been also performed to analyze the binding mode of compounds and the results sh...
متن کاملSYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF 7;3-[2-(2-AMINOTHIAZOL-4-YL)ACETAMIDO]CEPHALOSPORIN DERIVATIVES VI. ALTERNATIVE SYNTHESES OF 7t3-[2-(2-AMINOTHIAZOL-4-YL)-(Z)-2-METHOXYIMI NO- ACETAMIDO]CEPHALOSPORIN DERIVATIVES
An extensive study" of structure-activity relationships of 7,3-[2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]cephalosporins (1) and related compounds led to the selection of 7~-[2-(2-aminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido]-3-[(1-methyl-I H-tetrazol-5-yl) thiomethyl] ceph-3-em-4carboxylic acid (1a), cefmenoxime, for further biological evaluations. These Compounds (1) were prepared bas...
متن کامل